Radiesse as a biostimulator.

Take a biostimulator injection class at www.esiw.com 

 Radiesse is a dermal filler that has been traditionally used for soft tissue augmentation, particularly for the correction of facial wrinkles and folds. However, in addition to its filling properties, Radiesse also possesses biostimulatory effects, making it a versatile product for aesthetic and cosmetic treatments.

The main active ingredient in Radiesse is calcium hydroxylapatite (CaHA), which is a biocompatible and biodegradable substance. CaHA has a unique property of stimulating the production of collagen, a protein that provides structural support to the skin. When Radiesse is injected into the target area, the CaHA microspheres act as a scaffold for new collagen formation, leading to a volumizing and rejuvenating effect over time.

The biostimulatory properties of Radiesse make it useful for a variety of applications beyond mere wrinkle correction. It can be used to improve facial contours, restore facial volume loss, enhance cheekbones, and rejuvenate hands. By promoting collagen synthesis, Radiesse helps improve skin texture, elasticity, and overall skin quality.

The procedure involving Radiesse is minimally invasive and performed in a healthcare professional's office. The product is injected into the targeted area using a fine needle, and the treatment duration depends on the extent of the procedure. Some individuals may experience mild discomfort during the injection, but it is generally well-tolerated.

One of the advantages of Radiesse as a biostimulator is that its effects are not only immediate but also long-lasting. While the CaHA microspheres provide immediate volume and correction, the subsequent collagen synthesis helps to maintain the results. Over time, the CaHA is gradually metabolized by the body, leaving behind the newly formed collagen. The longevity of the results varies depending on various factors such as the individual's age, skin condition, lifestyle, and the treated area but can typically last for a year or more.

As with any medical procedure, there are potential side effects associated with Radiesse. These may include redness, swelling, bruising, itching, or tenderness at the injection site. However, these are usually mild and resolve on their own within a few days.

It's important to consult with a qualified healthcare professional who has experience with Radiesse or other dermal fillers to determine if it is a suitable option for your specific needs. They can assess your goals, explain the potential benefits and risks, and create a personalized treatment plan tailored to your desired outcome.

Get Hands-On Training in PDO Thread Lift at Esthetic Skin Institute www.esiw.com 

PDO thread lifting, also known as polydioxanone thread lifting, is a non-surgical cosmetic procedure that aims to lift and tighten sagging or aging skin. It involves the use of absorbable threads made of a biocompatible material called polydioxanone (PDO).

During a PDO thread lifting procedure, the threads are inserted into the skin using a fine needle or cannula. The threads have tiny barbs or cones along their length, which provide traction and anchor the threads in place once inserted. This helps to lift and reposition the skin, providing a subtle lifting effect.

The procedure is typically performed on areas of the face and neck that are prone to sagging, such as the cheeks, jowls, eyebrows, and neck. It can also be used to enhance the appearance of other areas of the body, such as the breasts or buttocks.

The PDO threads have two main effects on the skin. Firstly, they create an immediate lifting effect, repositioning the sagging tissues and restoring a more youthful contour. Secondly, the threads stimulate the production of collagen, a protein that provides structural support to the skin. Over time, as the threads dissolve, the newly formed collagen helps to improve skin elasticity and firmness, prolonging the effects of the treatment.

PDO thread lifting is considered a minimally invasive procedure, as it does not require large incisions or general anesthesia. It is typically performed in a clinic or medical spa setting and can be completed in about 30 minutes to an hour, depending on the area being treated.

After the procedure, some mild swelling, bruising, or redness may occur, but these side effects are temporary and generally subside within a few days. The results of PDO thread lifting are usually visible immediately, and they continue to improve over the following weeks as collagen production increases. The effects can last for several months to a year, depending on various factors such as individual skin characteristics and lifestyle factors.

Why is Esthetic Skin Institute one of the best schools around?

 www.esiw.com

The Esthetic Skin Institute (ESI) is a leading provider of hands-on training programs for medical professionals in the field of aesthetic medicine. The school has gained a reputation for excellence due to several factors that make it stand out from other training providers.

Firstly, ESI has a team of experienced and highly qualified instructors who are experts in their respective fields. Many of the instructors are board-certified dermatologists, plastic surgeons, and other medical professionals with years of experience in the field of aesthetic medicine. They bring a wealth of knowledge and expertise to the classroom, ensuring that students receive the most up-to-date and accurate training available.

Secondly, ESI offers a wide range of training courses, covering various aspects of aesthetic medicine, including Botox and dermal fillers, laser therapy, and chemical peels. The school provides both beginner and advanced level training programs, allowing medical professionals to tailor their education to their specific needs and experience levels.

Thirdly, ESI has state-of-the-art training facilities that are fully equipped with the latest technologies and equipment. The school has invested heavily in its facilities, ensuring that students have access to the most advanced equipment and techniques available in the field of aesthetic medicine.

Fourthly, ESI provides a hands-on approach to training, giving students the opportunity to work with real patients under the guidance of experienced instructors. This practical approach enables students to gain valuable experience and confidence in their skills, which is essential for success in the field of aesthetic medicine.

Finally, ESI has a strong commitment to student success, providing ongoing support and resources to help students achieve their career goals. The school offers post-training support, including access to online training materials, marketing and business development tools, and continuing education opportunities.

In conclusion, the Esthetic Skin Institute is a leading provider of hands-on training programs for medical professionals in the field of aesthetic medicine. With its experienced instructors, wide range of training courses, state-of-the-art facilities, hands-on approach, and commitment to student success, ESI has established itself as one of the best schools in the industry.

Why is Hands-on Botox Training Important?

 Botox, or botulinum toxin, is a popular cosmetic treatment used to reduce the appearance of fine lines and wrinkles by relaxing the muscles in the face. As the demand for Botox treatments increases, there is a growing need for qualified professionals who are trained in administering this treatment safely and effectively. Hands-on Botox training is an excellent way to acquire the necessary skills and knowledge to become a Botox injector.

Hands-on Botox training is a practical training course that teaches students how to inject Botox correctly and safely. The training usually consists of a combination of classroom lectures and hands-on practice sessions. During the lectures, students learn about the anatomy of the face and how Botox works to reduce the appearance of wrinkles. They also learn about the various types of Botox products available on the market, their differences, and how to choose the right product for each patient.

In the hands-on practice sessions, students are taught how to prepare Botox injections, how to inject them into specific areas of the face, and how to manage any side effects or complications that may arise. Students work with real patients under the supervision of experienced instructors, allowing them to gain valuable experience and confidence in administering Botox injections.

One of the significant advantages of hands-on Botox training is that it allows students to interact with real patients and gain practical experience. This experience is critical because every patient is unique, and injecting Botox requires a personalized approach. Hands-on training enables students to develop the skills necessary to evaluate patients, determine the appropriate dosage, and deliver injections accurately.

Another advantage of hands-on Botox training is that it provides students with the opportunity to learn from experienced instructors who can provide feedback and guidance. Instructors can offer valuable insights into injection techniques, dosage, and managing side effects, helping students to develop their skills and avoid common mistakes.

In conclusion, hands-on Botox training is an excellent way for medical professionals to acquire the skills and knowledge necessary to become proficient Botox injectors. With the increasing demand for Botox treatments, it is essential to have the proper training to ensure that patients receive safe and effective treatment. By taking hands-on Botox training courses, medical professionals can enhance their careers and provide their patients with the highest level of care.

With over 26 years of hands-on training around the country Esthetic Skin Institute is considered the number one choice for Certification

www.esiw.com

Diluted Radiesse to Tighten Skin on the Face and Body

 Diluted Radiesse to Tighten Skin on the Face and Body | RealSelf News

Chances are, you’re familiar with Radiesse. Since gaining FDA approval in 2006, some 6 million syringes of the filler have been injected deep in the skin, to restore lost volume and correct facial wrinkles and folds. Radiesse is frequently used to smooth smile lines, lift sunken cheeks, plump hands, and strengthen jawlines.

Recently, however, dermatologists and facial plastic surgeons have started using Radiesse in a unique way, by diluting (or when the ratio is 1:2 or higher, hyperdiluting) it with saline or lidocaine and injecting it more superficially, to address concerns related to skin texture and laxity—think fine wrinkles, crepiness, acne scars, and cellulite as well as saggy skin. It’s being used on the face, neck, chest, arms, abdomen, legs, and buttocks. 

“I love this technique,” says Dr. Jessie Cheung, a board-certified dermatologist in New York City and Chicago. “We’re not adding volume, but we see the skin tighten and shrink and become smoother.”

Interested in Radiesse?

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Radiesse vs. diluted Radiesse—what’s the difference?

A little refresher course on Radiesse: unlike hyaluronic acid (HA)–based filling materials like Juvéderm and Restylane, Radiesse works by stimulating your body to make collagen, the protein that plumps skin and keeps it smooth. The filler is made up of microspheres of calcium hydroxyapatite (CaHA), a substance also found in bones, that are suspended in a gel.

Like HA fillers, Radiesse works immediately to improve the treated area. But over time, the gel is fully absorbed and the body metabolizes the CaHA microspheres, leaving behind your own natural collagen, which lasts for 18–24 months. “In its unaltered form, Radiesse holds up well against gravity, which makes it an excellent filler for areas requiring a significant amount of structure and/or that are impacted by strong muscles, like the cheeks and jawline,” explains Dr. Heidi Waldorf, a board-certified dermatologist in Nanuet, New York, who was on the consensus panel that determined the preliminary guidelines for using hyperdiluted Radiesse.

Depending on how much Radiesse is diluted, the material has a mild volumizing effect, at best. Instead, it creates the equivalent of a gel mesh. “This initially holds an area more taut, but over time, it acts primarily as a biostimulator to improve the tone and texture and even tighten skin,” explains Dr. Waldorf. She uses it most commonly for the cheeks, neck, and chest in patients who have severe “solar elastosis,” or damaged collagen and elastin from sun exposure.

Tighten and smooth, from the neck down

This technique has been used in Europe for a few years, but it’s catching on more in the U.S. and should be widely adopted in 12–18 months, says Dr. Steven Weiner, a facial plastic surgeon in Santa Rosa Beach, Florida. He’s particularly a fan of using diluted Radiesse to treat “off-face” areas that weren’t being addressed completely with other modalities and “now can be treated with significant improvement, with minimal to no downtime and [few to no] risks.”

He uses it mostly for necks, on patients with mild to moderate laxity, as part of his Tri-NECK-ta treatment, which also includes Dysport (a botulinum toxin); Genius (radiofrequency microneedling, or RFM); or laser resurfacing. “I often inject Radiesse in the neck in combination with the Genius to improve wrinkles and skin integrity, and it actually tightens the skin, with or without RFM,” he says. Indeed, in one small study on the neck and décolletage, injections of diluted Radiesse stimulated significant amounts of collagen. The treatment, researchers concluded, was very effective for skin tightening in both areas.

Related: Hyaluronic Acid vs. Biostimulatory Fillers: What to Know Before You Get Injected

How diluted is diluted Radiesse?

Many experts have developed techniques for diluting CaHA, in ratios of anywhere from 1:1 to 1:6. Dilutions can be adjusted, depending on the thickness of a patient’s skin and the degree of tissue laxity, to ensure smooth placement. If not properly diluted, the material can look bumpy, especially if it’s injected too superficially. In one study where hyperdiluted Radiesse was used on the neck, researchers injected different dilutions based on skin thickness: 1:2 (normal skin), 1:4 (thin skin) and 1:6 (severely “atrophic” or aged skin).  

Diluted Radiesse is injected with a cannula or needle, with or without topical anesthetic, depending on whether Radiesse or Radiesse (+), which contains the anesthetic lidocaine, is used. Several injection techniques are used: for skin laxity, multiple cannula passages are made in patterns that resemble a fan or an asterisk. The material can also be injected in short, linear “threads.”  

As a bonus, the dilution eases the filler delivery for the injector. It also reduces filler thickness and facilitates its even spread, encouraging skin stimulation through more direct contact with tissues and minimizing unevenness. 

As with any filler injection, there can be a variable amount of bruising and swelling, which normally lasts up to a week. “Although uncommon because of the thinning of the product, if a bump is seen or felt after swelling and bruising have resolved, it can be camouflaged with other filler or broken up with injection and massage,” says Dr. Waldorf.

When injecting diluted Radiesse, less is more to prevent excess swelling, especially when using higher dilutions, says Dr. Waldorf. For instance, when treating the neck, she’ll often use one syringe of Radiesse and then have the patient return in two to four weeks for another treatment. 

Interested in Radiesse?

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The “add-on” effect

Diluted Radiesse can be used alone, “but harder-to-treat concerns, like the neck, chest, and arms, invariably do best with a combination approach,” explains Dr. Waldorf. She says diluted Radiesse is a great adjunct to other tightening and resurfacing procedures, like Ultherapy, Thermage, and Fraxel, because they work together to improve dermal collagen. “Think of combination therapy like assembling an outfit—each piece of the outfit does something different, and together they make the look.” 

That said, in one study that evaluated the effectiveness of diluted Radiesse used by itself to tighten skin in the upper arms and abdomen, skin thickness significantly increased after a single treatment and 90% of participants and physicians rated the areas very much improved.

Diluted Radiesse is frequently also combined with traditional Radiesse injections. “Most patients want the straight filler effect,” says Dr. Cheung. “Spackling” or “frosting,” as she called treatment with diluted Radiesse, is additional. “You see the effects of the regular filler immediately and then see the collagen that diluted Radiesse stimulates after about a month,” Dr. Cheung explains. “Patients look good from the filler right away, then come back and say their skin looks tighter [and] smoother and that they look a little more lifted.” 

How much diluted Radiesse is needed, and what does it cost?

Radiesse is available by the syringe, and, according to the current practice guidelines, treatment typically requires one to two syringes. The face and neck each usually require a single 1.5cc syringe per session, while the chest requires a half to a full syringe. The buttocks require one syringe per cheek (for cellulite and sagging skin), and the thighs need one syringe per thigh area (inner or outer). The abdomen requires two syringes, one each for the upper and lower half. The knees and elbows require one syringe in total (half on each side), and the arms usually need between a half and a full syringe per arm. Usually, two sessions for fillers are necessary, spaced one or two months apart. 

Depending on what’s being treated, the treatment may be repeated at six months or a year. Preliminary research shows that results with diluted Radiesse may last up to two years. 

The average cost paid for Radiesse by RealSelf members is $1,050 per treatment. 

Source Revance Announces FDA Approval of DAXXIFY™ (DaxibotulinumtoxinA-lanm) for Injection, the First and Only Peptide-Formulated Neuromodulator With Long-Lasting Results | Business Wire 

NASHVILLE, Tenn.--(BUSINESS WIRE)--Revance Therapeutics, Inc. (Nasdaq: RVNC), a biotechnology company focused on innovative aesthetic and therapeutic offerings, today announced that the United States (U.S.) Food and Drug Administration (FDA) has approved DAXXIFY™ (DaxibotulinumtoxinA-lanm) for injection for the temporary improvement of moderate to severe frown lines (glabellar lines) in adults.1 DAXXIFY™ is the first and only neuromodulator stabilized with Peptide Exchange Technology™ (PXT) and is free of both human serum albumin and animal-based components.1-2,7-11 Most importantly, DAXXIFY™ has the ability to address duration of treatment effect, which we believe is the greatest unmet need with existing neuromodulators for both consumers and injectors.12 The FDA approval, Revance’s first, augments the company’s innovative aesthetics portfolio and expands the company’s access to the growing $3.2 billion U.S. facial injectables market, further establishing Revance as an innovation leader in the industry and laying the groundwork for potential future therapeutic indications.13

“With DAXXIFY’s innovative and differentiated performance profile, alongside our portfolio that includes the RHA® Collection of dermal fillers and the OPUL® Relational Commerce platform, we have a real opportunity to build on our commercial success while setting a new standard for neuromodulator formulation”

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“The FDA approval of DAXXIFY™ is a foundational achievement for the company as it marks the culmination of years of pioneering research and development made possible by the outstanding execution of our talented team, along with strong support from the medical and investor communities. It has been an incredible and rewarding journey to realize our vision and bring this disruptive innovation to an industry that has remained largely unchanged for over 30 years,” said Mark J. Foley, Chief Executive Officer. “Importantly, we are very pleased DAXXIFY™’s label includes data demonstrating the achievement of none or mild wrinkle severity based on investigator and subject assessments, as this provides the foundation for our marketing claims around duration of effect. We look forward to continuing to set new standards in aesthetics and to establishing a new category of long-lasting, peptide-enhanced neuromodulators.1,11”

Jeffrey Dover, MD, co-director of SkinCare Physicians of Chestnut Hill, commented, “As a SAKURA investigator, I’m pleased to see DAXXIFY™ now approved as the first and only peptide-formulated, long-acting neuromodulator in the market. Compelling data from the largest Phase 3 clinical program ever conducted for glabellar lines demonstrated that DAXXIFY™ was well tolerated and achieved clinically significant improvement with long-lasting results and high patient satisfaction. Notably, DAXXIFY™ was able to demonstrate a long duration of effect while only utilizing 0.18 ng of core active ingredient in the 40-unit labeled indication for glabellar lines. With today’s approval, I look forward to helping patients, who have been accustomed to a 3 to 4-month duration profile with conventional neuromodulators, achieve year-long results with as few as two treatments per year.2-5 *”

The U.S. approval of DAXXIFY™ was based on the data generated in the SAKURA Phase 3 clinical trial program (SAKURA 1,2,3), which included more than 2,700 patients and approximately 4,200 treatments. In the pivotal trials:

• 74% of subjects achieved a > two-grade improvement in glabellar lines at week 4 per both investigator and patient assessment1,4¶
• 88% achieved > two-grade improvement at week 4 per investigator assessment1¶
• 98% of subjects achieved none or mild wrinkle severity at week 4 per investigator assessment 4¶
• 6-month median duration3,4*
• Some patients maintained treatment results at 9 months2-4‡
• Results seen as early as one day after treatment, typically seen within two days14¶

DAXXIFY™ is generally safe and well tolerated with no serious treatment-related adverse events reported in the clinical trials and has a safety profile consistent with other currently available neuromodulators in the aesthetics market.1-5,7-10 The most common treatment-related adverse events with DAXXIFY™ observed in the pivotal trials were headache (6%) followed by eyelid ptosis (2%) and facial paresis, including facial asymmetry (1%).1

“With DAXXIFY’s innovative and differentiated performance profile, alongside our portfolio that includes the RHA® Collection of dermal fillers and the OPUL® Relational Commerce platform, we have a real opportunity to build on our commercial success while setting a new standard for neuromodulator formulation,” said Dustin S. Sjuts, President. “The strong inroads that we have made in the prestige market with our products and services will serve as a solid foundation upon which to launch DAXXIFY™. Consistent with our commercial strategy, DAXXIFY™ will be available through Revance Aesthetics’ elite partners, known for delivering exceptional consumer outcomes and experiences. We are excited to be launching DAXXIFY™ shortly with an early training and education program at our world-class headquarters and experience center in Nashville, followed by a broader commercial launch.”

Practices interested in receiving more information on DAXXIFY™ may reserve their spot at RevanceAesthetics.com.

Understanding Filler Rheology for Safer, More Attractive Injections Understanding the physicochemical properties of the different dermal fillers will help you deliver safer and more attractive outcomes.

Article Credit : Understanding Filler Rheology for Safer More Attractive Injections | MedEsthetics (medestheticsmag.com)

By Inga Hansen 

 In the past two decades, the number of dermal fillers in the U.S. market has increased by more than 100%, and consumer demand for these treatments has skyrocketed. Key to achieving optimal outcomes is understanding different fillers’ unique physicochemical properties and how that affects their behavior in the skin. “There are a lot of different words we use to describe filler properties: stretch, strength, lift and flexibility are just some of them. It doesn’t matter what you call them, you just need to know what goes where,” says Carolyn Jacob, MD, medical director of Chicago Cosmetic Surgery and Dermatology.

The core measure that injectors need to understand when determining which filler is most appropriate for specific anatomical regions is the filler’s rheology—how the material deforms and changes under mechanical stress. For “Rheologic properties of soft tissue fillers and implications for clinical use” (Journal of Cosmetic Dermatology, January 2021), Nazanin Saedi, MD, of the department of dermatology and cutaneous biology at Thomas Jefferson University in Philadelphia and colleagues compared the rheology of a wide range of dermal fillers.

They noted that the rheology of hyaluronic acid (HA) fillers is determined by the degree of cross-linking, HA particle size, gel concentration and length of the HA chains, with cross-linking and particle size being the key characteristics that define a filler’s behavior under mechanical stress.

“We often talk about high G’ when you want lift and volume, such as in the cheeks and jawline. But G’ isn’t everything when it comes to rheology and lifting capacity,” says Dr. Saedi. “Things to look at also are cohesivity and particle size. A lot of the Juvederm products have a lower G’, but they have more cross-linking so they’re more cohesive and can provide volume that way. Whereas some of the Restylane fillers use larger particle sizes of HA to provide lift. So, we need to understand that cross-linking, particle size and gel concentration all play a role.”

Filler Selection and Indications

Fillers such as Radiesse, Restylane Lyft and Juvederm Voluma XC offer the greatest lift and lowest risk of deformity against mechanical stress. They should not be injected superficially or in areas with a lot of mobility as they will create noticeable bumps, especially during facial movement. They do offer superior revolumization when used in the midface, jawline or hands. “Ten years ago, all we had were medium and low G’ fillers, so we had to put a lot of filler in the face to get volume and lift, and it did not look natural,” says Mariano Busso, MD, a dermatologist with practices in Miami, Florida and Beverly Hills, California. “These fillers allow you to get the most amount of lift with the least amount of product.”

Proper injection technique when performing deep injections in the cheeks to revolumize will help reduce the risk of granulomas and uneven volumization. “If you inject a lot of filler at once, it can be uneven,” says Dr. Busso. “But if you inject small amounts in tracks around the zygomatic bone laterally or superiorly for cheeks, for example, you nicely distribute the filler.”